During the same period, the San Pascual, the Asis, the San Lorenzo, the Santo Domingo and the San Augustin were built as twin ships.

The San Juan Nepomuceno was a solidly built ship of proven seaworthy qualities.

It was outfitted with a total of 74 cannons: 24 24-pound cannons, 30 18-pound cannons, 8 12-pound cannons, 8 8-pound cannons and was manned by: 8 Officers, 11 Midshipmen, 19 Leading seamen and 492 Able seamen. Its supply capacity was for 60 days victuals and 80 days water.

It rendered numerous important services to the Armada (fleet), some of them in the Caribbean where it participated in several sieges and was distinguished in 1779.

The battle of Trafalgar is the historical feat in which it participated and of which we have the best account. In spite of being unmasted by admiral Nelson's artillery on the 21st October 1805, it achieved glory in this battle under the command of the famous Brigadier Don Cosme Damian Churruca and constituted for the Spaniards a handsome example of the heroism of their race and the bravery of their sailors. The wounded Admiral Nelson continued to direct the battle, while the Brigadier Churruca, whose leg had been torn off by a Howitzer, the deck of his ship covered by the blood of his wounded and dead seamen, continued to voice the command "fire". However, unable to break the circle of fire formed by the six enemy ships, which counted among others with the famous Defiance, Tonnant and Dreadnought, the San Juan Nepomuceno yielded with over 400 dead and injured on board. The English obtained the victory but paid a high price in lives and material.

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